作者:Zhang; Ao; Fan; Lijing; Zhang; Zeyu; Zhu; Danqi; Hu; Biying; Xie; Ting; Liao; Zhennan 期刊:《临床医学工程》 2019年第S01期
Diabetic nephropathy is one of the most common causes of end-stage renal disease worldwide and is associated with increased mortality in patients with type 1 and type 2 diabetes.Autophagy is a highly conserved"autophagy"pathway and is an important mechanism for maintaining glomerular and tubular homeostasis.Emerging evidence suggests that targeted autophagy pathway activation and restoration of ...
作者:蒋超; 吴志宏; 邱贵兴; 王以朋 期刊:《中华骨与关节外科》 2014年第06期
软骨的破坏、缺损是包括骨关节炎(osteoarthritis,OA)在内的多种骨科疾病的重要病理改变。由于软骨特殊的解剖及组织特性,如缺乏血管和淋巴管的分布,使得其自我修复能力异常不足,因此通过人工方法修复软骨破坏具有重要临床意义。近年来,随着间充质干细胞(mesenchymal stem cells,MSCs)的发现和研究的深入,其来源广泛、良好的增殖能力、多分化潜能、与各种3D支架材料具有良好的生物相容性等特性使得其在软骨修复应用中具有令人...
作者:ZAI; Xuerong; DUAN; Zhiwei; CHEN; Wei; YU; Jian; FU; Yubin 期刊:《中国海洋大学学报·自然科学版》 2019年第06期
Improving the performance of anode is a crucial step for increasing output power of marine sediment microbial fuel cells(MSMFCs)to drive marine monitor to work for a long term on the ocean floor.A pyrolyzed iron phthalocyanine modified multi-walled carbon nanotubes composite(FePc/MWCNTs)has been utilized as a novel nodified anode in the MSMFC.Its structure of the composite modified anode and ele...
作者:ZENG; Ju; CHENG; Xiao-rui; ZHOU; Wen-xia; ZHANG; Yong-xiang 期刊:《中国药理学与毒理学》 2019年第09期
OBJECTIVE Chronic stress is one of the important factors in the development of many mental and neurological diseases,and cause damage to the central nervous system,affect animal emotions and damage the immune function of the body.The purpose of this study was to investigate the effects of LW-AFC which extracting from traditional Chinese medicine prescription Liuwei Dihuang decoctionon the anxiet...
作者:Valérie; SCHINI-KERTH 期刊:《中国药理学与毒理学》 2019年第09期
It is well established in experimental animals and Humans that endothelial cells,which cover the luminal surface of all blood vessels,have a pivotal role in the control of vascular homeostasis.The protective effect of endothelial cells is mostly due to their ability to respond to circulating hormones,autacoids,blood-and platelet-derived factors,and also to blood flow by inducing potent vasoprote...
作者:CAI; Bang-rong 期刊:《中国药理学与毒理学》 2019年第06期
OBJECTIVE Diosgenin(DG), a naturally occurring steroidal saponin, has been reported to offer a variety ofpharmacological activities including anti-diabetic and anti-tumor activity, anti-inflammatory and anti-AD. However, the clinical application of DG is limited by its extremely low solubility and poor pharmacokinetic profile. In the present report,a novel diosgenin derivative with improved wate...
作者:Yao; Zhang; Qi; Dong; Junwei; Chen; Ning; Wang 期刊:《医用生物力学》 2019年第A01期
作者:Xi; Chen; Kai; Tang; Jinghua; Sun; Yadi; Fan; Zhipeng; Xu; Mo; Yang; Youhua; Tan 期刊:《医用生物力学》 2019年第A01期
Cancer stem cells(CSCs)are the driving force for sustainable tumor growth and metastasis and responsible for drug resistance and cancer relapse.Nanoparticle-based drug delivery has been demonstrated to be effective in combating tumor growth.However,it has been challenging to selectively eliminate CSCs due to the lack of a general signature for a spectrum of cancers.It is known that CSCs from var...
作者:Xianmei; Liu; Xue; Xia; LAmy; Sung; Weijuan; Yao; Zhu; Zeng 期刊:《医用生物力学》 2019年第A01期
Background Dendritic cells(DCs)are the most important antigen-presenting cells due to their professional and extremely efficient antigen-presenting function.The dynamics of cytoskeleton plays crucial regulated roles on DCs’immune functions and biophysical properties.Several evidences show that tumor-derived suppressive cytokines deteriorate DCs’immune functions through remodeling their F-actin...
作者:Liming; Bian 期刊:《医用生物力学》 2019年第A01期
Objective The binding of cell adhesive peptides(such as RGD)to integrins initiates the recruitment of cytoplasmic adaptor proteins(e.g.,vinculin)and the formation of focal adhesion(FA)complexes required for cell adhesion.The ability to manipulate this ligand-mediated cell adhesion process is crucial for regulating cell migration,cell differentiation,injury healing,and immune response.Some recent...
作者:Dasen; Xu; Nu; Zhang; Hui; Yang 期刊:《医用生物力学》 2019年第A01期
Background Traffic accidents,anti-terrorism,gas and chemical dangerous goods explosions,earthquake shock wave damage,and falling impacts in daily life and other events involving impact loads cause great harm to human organs and tissues,and even life-threatening.Such injuries are called impact damage.Although during the previous wars,the treatment of impact injuries has been greatly improved,and ...
作者:Fan; Yuan 期刊:《医用生物力学》 2019年第A01期
Pulsed electric field has been used widely as a nonviral approach to improving gene delivery in basic and translational research[1-2].The technique has been called electrotransfection(ET),electroporation,electrogene transfer,and gene electroinjection in the literature [1,3].It has a great potential to improve clinical treatment of diseases through delivery of vaccines and therapeutic genes,genom...
作者:Xiqiao; Feng 期刊:《医用生物力学》 2019年第A01期
The dynamic behaviors of collective cells play a significant role in many physiological and pathological processes,e.g.,embryonic development and cancer metastasis.In this talk,theoretical models,numerical simulations,and experimental measurements are combined to investigate the dynamics of collective cells[1-5].First,cell division is the most fundamental process in embryonic development,tissue ...
作者:Huan; Yin; Lizhen; Wang; Bingmei; MFu; Yubo; Fan 期刊:《医用生物力学》 2019年第A01期
Introduction Primary cilium is a non-motile microstructure,protruding from cell surface of most mammalian cells.It was previously thought to be vestigial.However,recent studies indicate that it may serve as one of the most vital mechanosensors for many types of cells such as epithelial and endothelial cells and osteocytes.Protruding from the apical membrane,the primary cilium can directly sense ...
作者:Xue; Zhao; Jiangli; Liu; Yun; Wang; Shichao; Zhang; Jing; Zhou; Zhu; Zeng; Zuquan; Hu 期刊:《医用生物力学》 2019年第A01期
Objective Fumonisin B1(FB1)is an important mycotoxin in nature worldwide.The biomechanical properties of cells are closely related to their structure and function,and the cytoskeleton is the structural and functional basis of cells motility,and therefore,from a biomechanical point of view,the purpose of this study is to investigate the effects of FB1 on the biomechanical properties,migration cap...
作者:刘丹 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To observe effect of Yiqi Yangyin Quyu recipe (YYQR) containing serum on aquaporin protein-5(AQP5) and type 3 muscarinic acetylcholine receptors(M3R) of human submandibular gland cells with Sj?gren’s syndrome(SS). Methods YYQR containing serum was prepared.
作者:杨凯朝 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To investigate the effect of 2,2’,4,4’-tetrabromodiphenyl ether (PBDE-47) on the mitochondrial mass in rat adrenal pheochromocytoma (PC12)cells and the potential mechanisms. Methods Highly differentiated PC12 cells were divided into control,1,10 or20μmol/L PBDE-47-treated groups and cultured for 24 h.
作者:任莉莉 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To investigate effects of melatonin (MT)on high glucose-induced cell proliferation,Toll-like receptor4 ( TLR4) signaling pathway and expressions ofinflammatory factor in mouse mesangial cells ( SV40).Methods SV40 cells were divided into mannitol controlgroup ( 30 mmol /L mannitol ),normal control group(5 mmol /L glucose),control ( 5 mmol /L glucose) +1000 μmol /L MT group,high glucose ...
作者:邱惠军; 解子骁; 杨钦泰 期刊:《中国耳鼻咽喉头颈外科》 2019年第10期
辅助性T细胞1/辅助性T细胞2(T helper 1 cells/T helper 2 cells,Th1/Th2)免疫失衡、调节性T细胞/辅助性T细胞17(regulatory T lymphocytes/T helper 17 cells,Treg/Th17)比例下调以及树突细胞(Dendritic cell,DC)的活化等参与了变应性鼻炎(AR)的发生发展过程。Hippo通路是一种非常保守的信号传导通路,具有调节细胞增殖、凋亡的功能。新近的研究发现,Hippo信号通路中哺乳动物不育系20样激酶1/2、Yes相关蛋白和转录共激活因子PDZ结...
作者:吕晓丽; 杨易; 张馨月; 梁大栋; 刘俊渤; 唐珊珊; 靳瑞发 期刊:《结构化学》 2019年第09期
Here, a series of starburst triphenylamine(WD8) derivatives for dye-sensitized solar cells(DSSCs) applications have been designed. The frontier molecular orbitals(FMOs) property, absorption spectra, and charge transfer rate property of WD8 and its derivatives were simulated. We also evaluated the FMOs energies and absorption spectra of WD8 and its derivatives with the TiO2 cluster. The simulatio...