医用生物力学杂志 北大期刊 CSCD期刊 统计源期刊

Mechanical Properties of Cells Estimated by Different Models of Micropipette Aspiration

作者：Weiyi; Chen 刊期：2019年第A01期

面向3D打印植介入体的生物力学设计

作者：樊瑜波 刊期：2019年第A01期

医用植介入体至少包含两类重要的生物力学问题:一是其自身结构的强度等生物力学问题,二是与宿主之间的相互作用;二者对于其成败都非常重要。增材制造技术(3D打印)为个性化植入假体的应用推广带来希望,个性化植入假体具有巨大的临床和市场需求。然而,个性化植入假体设计与临床应用仍有亟待解决的科学和关键技术问题,现有的临床案例主要考虑基于解...

Molecular and Cellular Immuno-Engineering

作者：Peter; Yingxiao; Wang 刊期：2019年第A01期

Genetically-encoded biosensors based on fluorescence proteins(FPs)and fluorescence resonance energy transfer(FRET)have enabled the specific targeting and visualization of signaling events in live cells with high spatiotemporal resolutions.Single-molecule FRET biosensors have been successfully developed to monitor the...

Organization and Ultra-Structural Components of Endothelial Surface Glycocalyx Revealed by Stochastic Optical Reconstruction Microscopy(STORM)

作者：Jie; Fan; Yi; Sun; Yifan; Xia; John; M.Tarbell; Bingmei; M.Fua 刊期：2019年第A01期

Introduction The endothelial cells(ECs)lining every blood vessel wall constantly expose to the mechanical forces generated by the blood flow.The EC responses to these hemodynamic forces play a critical role in the homeostasis of the circulatory system.In addition to forming a transport barrier between the blood and v...

血流动力学调控血管重塑依赖性的斑马鱼尾部静脉血管的形成

作者：文霖; 王瑾暄; 金雪璞; 雷道希; 张涛; 邱菊辉; 王业启; 王贵学 刊期：2019年第A01期

血管新生是指血管内皮细胞在原有的血管基础上通过出芽、迁移和增殖等方式形成新的毛细血管网络。随后,为了进一步适应组织器官的氧和营养的需要,整个血管网络会进行血管重塑,在此过程中会选择性地修剪一些局部的毛细血管,进而成熟为具有明确分级的功能化的血管网络结构,这一过程叫做血管修剪(vascular pruning)[1-2]。越来越多的文献报道血流动...

Mechanosensing via Immunereceptors

作者：Cheng; Zhu; Wei; Chen; Jizhong; Lou; William; Rittase; Kaitao; Li 刊期：2019年第A01期

The immune response is orchestrated by a variety of immune cells,the function of which then is determined by the collective signals from different immunoreceptors.Recent studies have highlighted the presence of mechanical force on these receptor-ligand pairs and its important role in regulating antigen recognition/di...

Nuclear Mechanotransduction in Cellular Mechanobiology and Molecular Mechanomedicine

作者：Ning; Wang; Junwei; Chen; Jian; Sun; Erfan; Mohagheghian; Fuxiang; Wei 刊期：2019年第A01期

It is known that mechanical forces play critical roles in physiology and diseases but the underlying mechanisms remain largely unknown[1].Most studies on the role of forces focus on cell surface molecules and cytoplasmic proteins.However,increasing evidence suggests that nuclear mechanotransduction impacts nuclear ac...

How does Mechanical Loading Make Bone Microstructure: Modeling vs. Remodeling

作者：Samuel; T.Robinson; Yizhong; Hu; X.Edward; Guo 刊期：2019年第A01期

Bone modeling and remodeling are governed by distinct biochemical processes that may hold unique opportunities for optimizing bone mass[1,2].Remodeling refers to the coupled resorption and subsequent formation on the bone surface,while modeling represents uncoupled formation or resorption.Mechanical loading is known ...

Endocytosis and Vesicular Transport of Plasmid DNA in Cells During Electric Field-Mediated Gene Delivery

作者：Fan; Yuan 刊期：2019年第A01期

Pulsed electric field has been used widely as a nonviral approach to improving gene delivery in basic and translational research[1-2].The technique has been called electrotransfection(ET),electroporation,electrogene transfer,and gene electroinjection in the literature [1,3].It has a great potential to improve clinica...

Effect of Biophysical Cues on Cell Reprogramming

作者：Yang; Song; Song; Li 刊期：2019年第A01期

Cell reprograming technologies have broad applications in cell therapy,disease modeling and drug screening.Direct reprogramming is the process of converting from one cell type into a very distantly related cell type.In this direct conversion process,cells do not proceed through a pluripotent stage,which can be time-c...

Dynamics of Collective Cells

作者：Xiqiao; Feng 刊期：2019年第A01期

The dynamic behaviors of collective cells play a significant role in many physiological and pathological processes,e.g.,embryonic development and cancer metastasis.In this talk,theoretical models,numerical simulations,and experimental measurements are combined to investigate the dynamics of collective cells[1-5].Firs...

Mechanical Regulation of Calcium Response and Trail Formation of Neutrophils on Endothelium

作者：Yan; Zhang; Yanhong; Xu; Dandan; Huang; Yixin; Gong; Pan; Guo; Wenhui; Hu; Shouqin; Lü; Mian; Long 刊期：2019年第A01期

Atherosclerosis or fibrosis and cirrhosis undergo chronic inflammation associated with the adhesion between neutrophils and endothelial cells(ECs)that is mediated by their respective cellular adhesive molecules on stiffened blood vessel wall or extracellular matrix(ECM)under shear flow[1-3].However,the mechanical dep...

MRI-Based Patient-Specific Left Ventricular Model to Determine the Effects of Trabeculae Carneae on the Diastolic and Systolic Functions

作者：Fatemeh; Fatemifar; Marc; Feldman; Geoffrey; Clarke; Ender; Finol; Haichao; Han 刊期：2019年第A01期

Introduction Trabeculae carneae are irregular structures that cover the endocardial surfaces of both ventricles of human heart and account for a significant portion of the ventricular mass.However,the role of trabeculae carneae in left ventricular(LV)function is not well understood.Previous reports suggested that tra...

The Role of Non-Coding RNA in Vascular Remodeling Induced by Mechanical Stress

作者：Yingxin; Qi 刊期：2019年第A01期

Vascular remodeling is the essential pathogenic process of various cardiovascular disorders,including hypertension,atherosclerosis,stroke,and restenosis after vein graft.The main characterization of vascular remodeling is abnormal variations of vascular cell phenotype,morphological structure and functions such as mig...

3D Bio-Printed Glioblastoma-Vascular Niche Models

作者：Vivian; KLee; Hongyan; Zou; Roland; Friedel; Guohao; Dai 刊期：2019年第A01期

Introduction Glioblastoma multiforme(GBM),a malignant brain tumor,is highly invasive and use brain microvessels to migrate and invade.Studying the perivascular invasion/migration of GBM may enable new possibilities in GBM therapy.However,the lack proper 3D study models that recapitulate GBM hallmarks restricts invest...