作者:左京生; 于斌; 谢玉华; 陈少华 期刊:《实用心电学》 2010年第05期
作者:秦健; 黄如葵; 陈振东; 刘杏连; 梁家作; 陈小凤; 黄熊娟; 黄玉辉; 冯诚诚; 琚茜茜 期刊:《植物病理学报》 2019年第05期
苦瓜是葫芦科苦瓜属植物,在亚洲热带地区、东非、加勒比海等地区均有种植,是药食兼用的重要蔬菜,也是广西南菜北运的主要蔬菜品种[1,2]。据农业部门不完全统计,广西苦瓜的生产面积超过1.6万公顷,且逐年有增加的趋势。近年来,随着气候的变化,作物栽培面积的扩大,病害的发生也在不断增加。
作者:BAI; Shan-shan; ZHUO; Lin; SUN; Yi; SHI; Ru-ling; XIE; Yong-sheng; ZHANG; Wei 期刊:《中国药理学与毒理学》 2019年第06期
OBJECTIVE Extracellular amyloid-β(Aβ) plaques are one of the major pathological hallmarks of Alzheimer disease(AD). Therefore, decreasing Aβ levels is one strategyfor preventing the etiology of AD. Aβ peptides are generated from the cleavage of amyloid precursor protein(APP) by the β-secretase(BACE1) and γ-secretase(PS1). Inhibition of these secretases represents an obvious logical strategy to i...
作者:LI; Bin-bin; LIU; Ge; LIU; Rui; HE; Shu-cheng; LI; Xiang; HUANG; Liang-liang; WANG; Zi-yu; LI; Yun-man; CHEN; Yong-jian; YIN; Hong; FANG; Wei-rong 期刊:《中国药理学与毒理学》 2019年第09期
OBJECTIVE To study the therapeutic effects of TGP on SS both in C57BL/6J mice immunized by immu⁃nological induction(SS mice)and NOD/ShiltJNju(NOD)mice.METHODS TGP(180,360,720 mg·kg^-1)was intragastri⁃cally administered for 6 or 16 weeks for SS mice and NOD mice,respectively.Weekly food and water intake,saliva flow,submandibular gland(SMG)and spleen index,and SMG pathology were measured.ELISA w...
作者:HAN; Yi-fan; HU; Sheng-quan; Marvin; MAK; WANG; Jia-jun 期刊:《中国药理学与毒理学》 2019年第06期
Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic sta...
作者:GONG; Qi-hai; LI; Fei; JIN; Feng; WU; Qin; ZHANG; Feng; SHI; Jing-shan 期刊:《中国药理学与毒理学》 2019年第06期
Epimedium Brevicornum is a traditional Chinese medicinal plant possessing properties of sweet, warm, tonifying kidney, strong bones and rheumatism. Icariin, a flavonoid compound, is one of the main active ingredients of Epimedium. Icariinriside(ICS) is the main metabolite of icariin. Icariinand ICS have multiple pharmacological effects such as anti-tumor, anti-oxidative stress, improvement of ca...
作者:ZHOU; He-feng; SHAO; Min; GUO; Bao-jian; LI; Chu-wen; LU; Yu-cong; YANG; Xuan-jun; LI; Sheng-nan; LI; Hai-tao; ZHU; Qi; ZHONG; Han-bing; WANG; Yu-qiang; ZHANG; Zai-jun; LU; Jia-hong; LEE; Ming-yuen; Simon 期刊:《中国药理学与毒理学》 2019年第09期
OBJECTIVE To investigate the effects of T-006(tetramethylpyrazine derivative)in promotingα-Synuclein(α-Syn)degradation and evaluated the neuroprotective effects in cellular and animalα-Syn model of Parkinson disease(PD).METHODS The inducible PC12 cells overexpressingα-syn and the homozygous transgenic(Tg)mice expressing A53T humanα-syn were used to evaluate the neuroprotective effects of T-006.F...
作者:WANG; Xiao-lin; DENG; Yu-xin; GAO; Yu-mei; DONG; Yang-ting; WANG; Fan; GUAN; Zhi-zhong; HONG; Wei; QI; Xiao-lan 期刊:《中国药理学与毒理学》 2019年第06期
OBJECTIVE Alzheimer disease(AD) is the most common type of dementia and is featured by the accumulation of β-amyloid peptide(Aβ) in the brain. The Alpha 7 nicotinic acetylcholine receptor family(α7 nAChR) was widely considered to interact with that Aβ, mediate neuroprotection and improve cognitive performance. However, the mechanisms underlying these interactions remain elusive. The present stud...
作者:CUI; De-hua; ZHAO; Lei; WANG; He-cheng; HAN; Hong-bin 期刊:《中国药理学与毒理学》 2019年第06期
The most common age-related neurodegenerative disease is Alzheimer disease(AD),the imbalance between Aβ generation and clearance accumulated in extracellular plaques(ECS). And aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles, together with loss of cholinergic neurons, synaptic alterations, and chronic inflammation within the brain. These lead to progressive imp...
作者:Leo; Q.Wan 期刊:《医用生物力学》 2019年第A01期
Cell and Tissue Engineering provides exciting opportunities for studying development and Disease.In this talk,we will focus on cell chirality,also known as handedness and left-right(LR)asymmetry,which is an intrinsic capability of the cell telling left from right(1)The development of the vertebrate body plan with left-right asymmetry requires the emerging chiral morphogenesis at multicellular le...
作者:Xuequan; Han; Zihao; He; Linyang; Chu; Kai; Xie; Xu; Jiang; Mengning; Yan; Zhifeng; Yu 期刊:《医用生物力学》 2019年第A01期
作者:周香雪 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To study the clinical symptoms,coppermetabolism and imaging characteristics of Wilson disease(WD) carriers and to explore the treatment strategy ofWD carriers. Methods Forty WD carriers,40 WD patientsand 20 normal controls from the First AffiliatedHospital of Sun Yat-sen University from July 2007 to May2018 were included. The modified Young scale was usedfor neural symptom scoring,and ...
作者:刘媛媛 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To explore the interaction of angiotensinconverting enzyme (ACE) insertion /deletion(I /D) polymorphism( rs1799752 ) with diabetic kidney disease(DKD) development as well as its interaction with smokingand obesity in Chinese type 2 diabetic mellitus(T2DM) using an improved experiment method. MethodsFrom June 2016 to March 2018,300 T2DM patientswith DKD [DKD( +)]and 300 T2DM patients wi...
作者:李妍 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To explore the features of connectedspeech produced by Chinese mild Alzheimer's disease(AD) patients. Methods Thirty Chinese mild AD patients( eight males and 22 females,and the age was(72. 73 ± 7. 78 ) years) and 30 age-and educationmatchednormal controls from three communities were recruitedin Xuanwu Hospital from January 2018 to May2018. All subjects completed tasks of picture namin...
作者:林炳辉 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To explore the correlation between D-dimer (D-D),procalcitonin (PCT),vitamin D (VitD)and coronary artery disease (CAD). Methods 180 patients with CAD were divided into stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group according to ACC/AHA diagnostic guidelines.
作者:许旌 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To observe the changes of cognitive function,clinical characteristics and hippocampal structure in elderly patients with non-alcoholic fatty liver disease(NAFLD). Methods From December 2014 to June2016,at Department of Geriatrics,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,169 Elderly hospitalized patients whounderwent health check-ups were ...
作者:李谨 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To analyze the clinical features and clinicalsignificance of patients with inflammatory bowel disease( IBD) complicated by thrombosis. Methods From March 14th,2001 to February sixth 2017,at NanjingGeneral Hospital of Nanjing Military Command,27 IBDpatients with thrombosis diagnosed by clinical symptoms,endoscopy,imaging and pathology were enrolled. Duringthe same period,81 gender and a...
作者:唐向阳 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
作者:汤双红 期刊:《中国医学文摘·耳鼻咽喉科学》 2019年第02期
Objective To observe the effects of acupuncture at'Baihui'(GV 20) and'Shenshu'(BL 23) on the ultrastructure of hippocampal dentate gyrus in rats with Alzheimer’s disease. Methods Forty SPF Wistar male rats were randomly divided into normal group,sham operation group,model group and acupuncture group,10 rats in each one.
作者:徐景升; 许莉萍; 阙友雄; 高三基; 陈如凯 期刊:《热带亚热带植物学报》 2008年第02期
综述了近年来甘蔗宿根矮化病的检测、传播、防治及其致病菌Leifsonia xyli subsp, xyli的分类归属和致病机理等方面的研究进展,并探讨了研究策略。