医用生物力学杂志 北大期刊 CSCD期刊 统计源期刊

Mechanics and mechanotransduction of tumorigenic cells

作者：Youhua Tan Junwei Chen Arash Tajik Yeh-chuin Poh Ning Wang 刊期：2013年第S1期

Stimuli-responsive nano-reserveriors drug delivery systems based on inorganic nanoparticles

作者：Kaiyong Cai Zhong Luo Yan Hu 刊期：2013年第S1期

Cyclic mechanical stretch regulates MMPs and TIMPs expression in corneal fibroblasts

作者：Chengxing Liu Pengfei Feng Xiaona Li Xiaojun Wang Weiyi Chen 刊期：2013年第S1期

Laser in situ keratomileusis(LASIK)is a relatively new ophthalmic procedure in refractive surgery.It involves the use of a microkeratome to create a thin corneal flap followed by excimer laser ablation of the corneal stroma and repositioning of the flap.However,complications are bound to occur when a surgical procedu...

生物力学建模及应用的几个研究

作者：樊瑜波 刊期：2013年第S1期

生物力学建模及数值模拟技术已成为骨外科、口腔、人体防护等相关问题研究的一种重要手段。本文结合脊柱、口腔、眼部、膝关节、头颈等医学、防护相关问题,开展生物力学建模与数值模拟研究。1.啄木鸟头部的生物力学建模及模拟研究头部冲击性损伤主要是由于突然性的线性或旋转加速度造成的,多发于汽车碰撞、航空救生及体育运动中,其死亡率高、危...

Endothelial surface glycocalyx and vascular mechano-sensing and transduction

作者：Wanyi Yen Jinlin Yang Min Zeng John M.Tarbell Bingmei M.Fu 刊期：2013年第S1期

Introduction The endothelial cells(ECs)lining every blood vessel wall constantly expose to the mechanical forces generated by the blood flow.The EC responses to these hemodynamic forces play a critical role in the homeostasis of the circulatory system.In addition to forming a transport barrier between the blood and v...

Image-based nonlinear finite element analysis for the assessment of bone strength

作者：He Gong Yubo Fan Ming Zhang Ling Qin 刊期：2013年第S1期

Introduction As a major component of musculoskeletal system,bones support body weight,facilitate body motion,protect internal organs,and also play critical roles in mineral homeostasis.Osteoporosis,one of the most common bone diseases,is a result of imbalance in bone metabolism that causes low bone mass and micro-arc...

Probing membrane dynamics in living cells with spot-variation fluorescence correlation spectroscopy

作者：Haitao He 刊期：2013年第S1期

Cell membranes actively participate in numerous cellular functions.Inasmuch as bioactivities of cell membranes are known to depend crucially on their lateral organization,much effort has been focused on deciphering this organization on different length scales.Within this context,the concept of lipid-dependent membran...

Cell traction force distribution and its implications in cell adhesion and migration

作者：Shijie He Yewang Su Baohua Ji 刊期：2013年第S1期

Cell-matrix interaction is the key for understanding the cell behaviors,especially the mechanosensitivity of cell adhesion,cell migration and differentiation,etc.Cells are constantly probing,pushing and pulling on the surrounding extracellular matrix.These cell-generated forces drive cell migration and tissue morphog...

从生物力学到力学生物学的思考

作者：姜宗来 刊期：2013年第S1期

生物力学(biomechanics)是研究生命体变形和运动的学科,通过生物学与力学原理方法的有机结合,认识生命过程的规律,解决生命与健康领域的科学问题。现代生物力学就是对生命过程中的力学因素及其作用进行定量研究。现代生物力学之父-冯元桢(Y.C.Fung)先生在谈及生物力学对健康科学有何贡献时认为,"绝大多数生物力学工作的目的是为了丰富生命系统的...

力学敏感TRPC通道介导心肌细胞肥大的力学门控新机制初探

作者：刘小菁 李君丽 陈晓莹 吴文超 李良 刊期：2013年第S1期

Biophysical regulation of cell reprogramming

作者：Song Li 刊期：2013年第S1期

Biophysical factors can regulate many aspects of cell functions,including proliferation,migration and differentiation.In general,biophysical factors activate a myriad of signaling events;however,whether there is a common paradigm for various mechnotransduction processes is not clear.Here we use cell reprogramming as ...

Atheromatous plaque rupture may due to fatigue crack growth under cyclic blood pressure:A comparison between symptomatic and asymptomatic individuals

作者：Xuan Pei Zhiyong Li 刊期：2013年第S1期

Introduction Stroke or heart attack,the leading cause of death and disability worldwide,is usually caused by rupture of atheromatous plaque.Therefore,the identification of vulnerable atheroma pre rupture has become extremely important for patient risk stratification.Previous studies have shown that the vulnerable pla...

In vivo bone dynamic imaging of PTH’s anabolic effect

作者：Allison R.Altman Chantal de Bakker Wei-Ju Tseng Beom Kang Huh Abhishek Chandra Ling Qin X.Sherry Liu 刊期：2013年第S1期

Introduction Aging shifts bone remodeling toward a negative balance between bone formation and resorption,causing bone loss and increased fracture risk.Anti-resorptive agents are commonly used to inhibit bone resorption and stabilize bone mass.While they are effective to prevent further bone loss,there is also a grea...

Mechanism of mechanical regulated Notch activation and structural bases of Notch NRR related T-lineage acute lymphoblastic leukemia(T-ALL)

作者：Jizhong Lou 刊期：2013年第S1期

Computational analysis of spatiotemporal molecular hierarchy in single live cells

作者：Shaoying Lu Jihye Seong Yi Wang Shiou-chi Chang John Paul Eichorst Mingxing Ouyang Yingxiao Wang 刊期：2013年第S1期

Genetically encoded biosensors based on fluorescence resonance energy transfer(FRET)have been widely applied to visualize the molecular activity in live cells with high spatiotemporal resolution.The enormous amount of video images and the complex dynamics of signaling events present tremendous challenges for data ana...