摘要:目的探讨Sonichedgehog(SHH)在肝细胞癌(HCC)和癌周肝组织中的表达及其临床意义。方法检测145例HCC和癌周肝组织SHH的表达,了解其表达与患者根治性切除术后预后的关系。检测4种肝癌细胞株以及正常肝细胞株SHHmRNA的含量。结果SHH主要表达于肝细胞和肝癌细胞的胞质,肝癌与癌周肝组织表达差异无统计学意义(P〉0.05)。癌和癌周高表达的患者总体生存率显著高于低表达患者(P〈0.05)。肝癌细胞株SHH表达量显著高于正常肝细胞株(P〈0.01)。结论SHH在HCC和癌周肝组织中高表达,其表达可用于区分患者预后,SHH可能参与HCC的发生和发展。
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