摘要：91-95.Objective To investigate the expression of transcriptionfactor forkhead /winged helix transcription factor 3(Foxp3),immune factor transforming growth factor-beta1 (TGF-β1),and T-lymphocyte activation related factorinterleukin-2 (IL-2) in peripheral blood of patients withcoal-burning arsenic poisoning,and to analyze the effectsof arsenic exposure on immune function. Methods Acase-control study was conducted to investigate 149 cases[94 males and 55 females,(50. 69 ± 6. 14) years old]of arsenic poisoning in Yuzhang coal-burning arsenic poisoningarea,southwestern Guizhou Province,and the caseswere diagnosed based on the“Diagnosis of EndemicArsenicosis”(WS /T 211-2015) and confirmed by clinicalreview. According to skin damage,the patients weredivided into mild arsenic poisoning group (39 cases),moderate arsenic poisoning group (54 cases) and severearsenic poisoning group ( 56 cases );and 41 cases[12 males and 29 females,(45. 76 ± 7. 88) years old]of non-arsenic exposed residents from 12 km of Yuzhangcoal-burning area were selected as control group. Morningurine and peripheral blood samples were collectedwith informed consent.

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