摘要:溶质载体家族22(SLC22A)是一组膜转运蛋白,含有至少31个已知的成员,其底物具有广谱性,可参与肝脏毒素、药物和内源性代谢产物跨细胞膜的转运,在介导肝脏摄取多种临床药物中起关键作用,并且在各类肝脏疾病中表达异常。SLC22A的遗传及非遗传变异促进肝脏疾病进展,影响肝脏药物代谢和靶组织摄取,当转运体功能发生改变时对突变患者治疗的有效性和毒性亦有影响;除此之外,部分SLC22A可作为肝癌早期诊断及疗效评估的生物标志物。
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