摘要:目的探讨中期因子(midkine,MK)在卵巢上皮肿瘤中的表达及与其临床病理特征的关系。方法采用双抗体夹心法(ELISA)检测50例上皮性卵巢癌、50例良性上皮性卵巢肿瘤及40例正常女性血清MK浓度。结果卵巢癌组血清MK含量明显高于卵巢良性肿瘤组与正常对照组的血清MK含量(P〈0.05),而卵巢良性肿瘤组与正常对照组的血清MK含量接近,差异无统计学意义(P〉0.05);随着临床分期的提高,血清MK值逐渐增高;MK表达与肿瘤病理类型无相关性(P〉0.05);随着病理分级的提高.血清MK值逐渐增高。结论卵巢癌患者血清MK含量明显高于卵巢良性肿瘤和正常人群,并与TNM分期和病理分级成正相关,MK可作为1种有价值的肿瘤标志物。
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