摘要:目的:探究锌指蛋白Snail与转录调节因子核因子-κB(nuclear factor-κB,NF-κB)在宫腔粘连(intrauterine adhesions,IUAs)患者子宫内膜中的表达。方法:选择34例宫腔粘连患者作为试验组(IUAs),非宫腔粘连患者19例作为对照组(control),在宫腔镜直视下取子宫内膜组织。采用实时荧光定量PCR、免疫组织化学和Western blot分别检测NF-κB、Snail、E-cadherin、Vimentin mRNA水平和蛋白水平的表达。结果:与对照组相比较,宫腔粘连患者子宫内膜组织中NF-κB(2.478±0.279 vs.1.459±0.323,P=0.013)、Snail(2.801±0.502 vs. 1.218±0.313,P=0.005)、Vimentin(3.581±0.650 vs. 1.756±0.260,P=0.006)的表达明显升高,E-cadherin(1.324±0.617 vs. 2.784±0.647,P=0.023)表达明显降低。结论:NF-κB和Snail可能参与了宫腔粘连的发生发展。
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