摘要:目的研究Nuclear factor-κb(NF-κB )/p65靶基因表达与胃粘膜不同类型肠上皮化生的关系.方法采用HID/AB/PAS方法检测肠化生上皮中粘液性质;S-P免疫组化法检测98例胃窦活检肠上皮中NF-κB/p65,C-myc、cyclinD1表达.结果 NF-κB/p65,C-myc,cyclinD1在III型肠化中阳性表达最高,分别为:29/35、30/35、28/35,明显高于I型、II型肠化且有显著性差异;而在Ⅰ、Ⅱ、Ⅲ级肠化中表达无显著性差异.结论 III型肠上皮化生中NF-κB/p65,C-myc、cyclinD1的高表达, 可能是胃癌发生过程中的重要分子生物学事件.
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