摘要:目的探讨建立MRL/lpr狼疮虚热证小鼠模型的方法。方法取MRL/1pr狼疮小鼠随机分为两组,模型组给予长时间灌胃附子、肉桂、干姜(1:1:1)水煎液,空白对照组灌胃同次数等量生理盐水,造模结束后,检测MRL/lpr狼疮小鼠血清中T3、T4、E2、T、COR的变化。结果造模结束后,模型组MRL/1pr狼疮小鼠血清中T3、T4、E2、COR的含量均高于空白对照组,T的含量低于空白对照组,出现中医虚热证的临床表现。结论利用温热中药水煎剂灌胃造模复制MRL/lp浓疮虚热证小鼠模型的方法是可行的。
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