摘要：Inv(16)(p13q22)或t(16;16)(p13q22)是急性髓系白血病(AML)特征性染色体异常,通常见于AML-M4EO亚型,占总AML患者的5%[1].其分子特征为CBFB/MYH11融合基因形成.最新WHO分型中inv(16)/HY11-CBFB为一个独立类型[2].我们应用荧光原位杂交(FISH)技术对临床上诊断为M4EO及伴有嗜酸粒细胞增高的AML患者进行研究,回顾性分析inv(16)患者临床与实验室特点.
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