摘要：目的探讨胸腺瘤病人TNF基因多态性及其与胸腺瘤发生重症肌无力的关系.方法应用聚合酶链反应-限制性片段长度多态性分析方法(PCR-RFLP)对36例胸腺瘤病人(其中合并重症肌无力12例),与90例健康对照者TNFa和TNFβ基因的NcoI酶切位点进行对比分析.结果胸腺瘤病人中TNFa的基因型和等位基因频率与正常对照人群无差异;TNFβ*2等位基因频率明显高于对照人群,提示该基因与胸腺瘤的发生相关,TNFa 1/1基因型胸腺瘤病人发生重症肌无力的比率明显增加.结论TNF基因多态性与胸腺瘤发病及胸腺瘤发生重症肌无力相关.
注：因版权方要求，不能公开全文，如需全文，请咨询杂志社
热门期刊服务
The Journal of China Universities of Posts and Telecommunications Control Theory and Technology Journal of Semiconductors Research in Astronomy and Astrophysics Transactions of Nonferrous Metals Society of China China Petroleum Processing Petrochemical Technology Tsinghua Science and Technology High Technology Letters Earthquake Engineering and Engineering Vibration Journal of Wuhan University of Technology Communications in Theoretical Physics Hepatobiliary Pancreatic Diseases International