摘要：Objective To analyze the clinical characteristics ofantiphospholipid syndrome (APS) patients with chronicthromboembolic pulmonary hypertension ( CTEPH ).Methods A total of 22 APS patients with CTEPH wereenrolled in our study,who were admitted in PekingUnion Medical College Hospital from January 2012 toAugust 2018. Diagnoses were confirmed by computed to-mographic pulmonary angiography (CTPA),or pulmonaryangiography. Demographic characteristics, clinicalmanifestations,laboratory tests,therapy,World HealthOrganization (WHO) functional class were retrospectivelycollected. Results There were 15 females and 7 maleswith a median age of 29-year-old. Chest pain (6 cases),dyspnea on exertion (22 cases),cough (6 cases) andhemoptysis ( 9 cases) were the most common clinicalmanifestations. Lupus anticoagulant ( LA),anticardiolipin(ACL) antibodies and anti-beta 2 glycoprotein Ⅰ(anti-β2 GPⅠ) antibodies were all positive in 12 patients,two of three antibodies positive in 5 patients,onlyone positive in 5 patients.

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