摘要:Objective To explore the mediating effect of hemoglobin(Hb)and hematocrit(HCT)on the association between alcohol consumption and blood pressure,and provide evidence for the prevention and control of alcohol-attributed hypertension.Methods 1 091 male(age>50 years old)participants with drinking habit were selected from the Guangzhou biobank cohort study(GBCS).Mediation analysis was used to evaluate the mediating effect of Hb and HCT on the association of alcohol consumption(unit/day)with systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP)and mean arterial pressure(MAP).Results After adjusting for age,body mass index,education level,personal annual income,smoking,occupation and physical activity,the associations of alcohol consumption with SBP,DBP,PP and MAP were partly mediated by Hb,the proportion of mediating effect was 11.8%(95% CI 4.8%-24.7%),15.3%(95% CI 6.5%-32.0%),8.4%(95% CI 2.2%-22.5%)and 13.5%(95% CI 5.9%-27.5%),respectively.The association of alcohol consumption with SBP,DBP,and MAP were also partly mediated by HCT,the proportion of mediating effect was 6.3%(95% CI 1.0%-16.0%),8.7%(95% CI 1.4%-21.4%),and 7.5%(95% CI 1.0%-18.6%),respectively.Conclusion There is a significant mediating effect of Hb and HCT on the association between alcohol consumption and blood pressure.Besides effects on alcohol control,the potential effects of alcohol-induced increase on Hb and HCT,which might also increase the blood pressure,need to be considered to achieve optimal monitoring and prevention of alcohol-related hypertension.
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Rare Metals 十万个为什么 Acta Mechanica Sinica Acta Metallurgica Sinica Chinese Medical Journal Numerical Mathematics Acta Mechanica Solida Sinica Biomedical and Environmental Sciences Chinese Journal of Mechanical Engineering Chinese Journal of Polymer Science Applied Mathematics and Mechanics Chinese Journal of Integrative Medicine