摘要:目的研究TNF-α、IFN-γ对正常人颊黏膜成纤维细胞(NM-FB)和口腔黏膜下纤维化(OSF)患者颊黏膜成纤维细胞(OSF-FB)胶原合成的影响.方法取6例OSF患者及5例正常人颊黏膜组织,采用组织块法进行成纤维细胞原代培养并传代,用羟脯氨酸试剂盒观察不同浓度TNF-α及IFN-γ对NM-FB和OSF-FB胶原合成的影响.结果浓度为100~10000 U/mL的TNF-α能明显促进NM-FB和OSF-FB的胶原合成(P<0.05),浓度为40~4000U/mL r IFN-γ则明显抑制两者的胶原合成(P<0.05),且400U/mL的IFN-γ其抑制率接近峰值(与4 000U/mL的IFN-γ组比,P>0.05).结论TNF-α促进NM-FB和OSF-FB的胶原合成,而IFN-γ对两者的胶原合成具有抑制作用.
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