摘要:目的探讨肝郁证、脾虚证的分子免疫学机制及二者的相互关系.方法应用RT-PCR法以及Western-blot法检测柴胡疏肝散、四君子汤对肝郁证、脾虚证模型大鼠T细胞NF-ATc mRNA及蛋白质表达水平影响.结果与正常组比较,肝郁组NF-ATc mRNA及蛋白质表达较明显降低(P<0.05),脾虚模型大鼠NF-ATc mRNA及蛋白质表达则明显升高(P<0.05).用柴胡疏肝散治疗后,与正常组比较,肝郁组NF-ATc mRNA及蛋白质表达上调,基本恢复了正常水平(P>0.05),脾虚组则无明显变化(P<0.05);而四君子汤治疗后,脾虚组NF-ATc mRNA及蛋白质表达下调(P>0.05),肝郁组则无明显变化(P<0.05).结论肝郁证与脾虚证的免疫功能失调与NF-ATc的表达异常密切相关;NF-ATc通过调节肝郁证与脾虚证的不同细胞因子的表达,介导二者Th0细胞向Th1、Th2不同的方向分化;柴胡疏肝散、四君子汤通过不同的免疫调节功能,调节NF-ATc表达,使其恢复正常水平.
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