摘要:目的探讨JMJD1A促进胶质瘤增殖侵袭的分子机制。方法通过Western Blot方法和利用TCGA数据库,分析胶质瘤组织中JMJD1A的表达情况。在胶质瘤细胞系U87和U251中,通过siRNA瞬时干扰JMJD1A的表达;利用体外实验方法检测JMJD1A干扰对细胞功能变化的影响。结果与正常脑组织相比,胶质瘤组织中JMJD1A蛋白及mRNA水平均显著升高;干扰JMJD1A表达后,胶质瘤细胞的增殖及侵袭能力显著下降。结论JMJD1A具有促进胶质瘤细胞增殖和侵袭的作用。
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