摘要:肿瘤的发生发展与免疫系统关系密切。程序性死亡受体1(programmed death receptor-1,PD-1)主要表达于T细胞等免疫细胞表面。程序性死亡受体配体1(programmed cell death ligand-1,PD-L1)表达于多种肿瘤细胞表面,包括肺癌、黑色素瘤、卵巢癌、肾癌、口腔鳞状细胞癌等,与PD-1结合后可抑制T细胞迁移、增殖和杀伤功能,实现肿瘤免疫逃逸。肿瘤细胞通过多种机制逃避免疫系统攻击,PD-1/PD-L1信号通路是其主要机制之一。
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