摘要:炎症小体是多蛋白复合物,可以招募并诱导半胱氨酸天冬氨酸酶-1前体(pro-caspase-1)成为有活性的半胱氨酸天冬氨酸酶-1(caspase-1),从而促进IL-1β和IL-18成熟与释放。许多研究表明NLRP3炎症小体与缺血性脑卒中、阿兹海默症(AD)、外伤性脑损伤(TBI)、脑瘤等神经血管疾病的发生发展密切相关。本文综述了NLRP3炎症小体激活途径,并着重介绍了NLRP3炎症小体介导的在上述几种神经血管疾病中的作用,为相关研究提供了基础资料。
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