摘要:神经干细胞(NSCs)在脑缺血后神经功能障碍的修复过程中起着关键作用。Notch通路广泛存在于动物细胞中,是调控NSCs增殖、分化的经典信号通路。Wnt通路参与细胞的增殖、分化和凋亡等过程,在损伤后脑组织NSCs增殖过程中发挥重要作用。近年来研究发现,两条通路形成一个信号网络,共同调控NSCs增殖和分化。
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