摘要:目的:探讨心肌素(Myocardin)和NF—κB在子宫平滑肌瘤发病中的作用机制。方法:对78例子宫平滑肌瘤标本和75例正常子宫肌层组织标本分别应用免疫组化En Vision法检测Myocardin与NF—κB的表达情况。结果:Myocardin在子宫平滑肌瘤中的阳性表达强度弱于正常子宫肌层(t=2.751,P=0.032;t=5.672,P=0.018),两种类型的子宫平滑肌瘤中Myocardin表达水平差异无统计学意义(t=0.854,P=0.681);NF—κB在子宫平滑肌瘤中的表达率高于正常肌层(P〈0.05),两种类型的子宫平滑肌瘤中NF—κB差别无统计学意义(χ^2=0.154,P=0.695);Mycardin与NF—κB的表达率有相关性(r=0.983,χ^2=736.328,P=0.032)。结论:在子宫平滑肌瘤的发生中,Myocardin可能起抑制作用,而NF—κB则可能起到促进作用,具有临床参考价值。
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