摘要:目的探讨IL-12对伯氏疟原虫(P.b)红内期感染小鼠淋巴细胞增殖活性的影响.方法每只BALB/c小鼠接种5×105个感染P.b的RBC,同时每天分别给予0.03或0.15 μg IL-12处理,用3H-TdR掺入法检测脾淋巴细胞增殖转化活性,流式细胞仪测定T淋巴细胞亚群CD4+与CD8+百分比.结果每天给予0.03或0.15 μg IL-12处理,均可显著增加P.b感染小鼠脾淋巴细胞数量及CD4+、CD8+数.每天给予0.03 μg IL-12可显著促进脾淋巴细胞的增殖转化,而每天给予0.15 μg IL-12则明显抑制脾淋巴细胞增殖.结论适当低剂量IL-12可促进P.b感染小鼠脾淋巴细胞增殖活性,增强机体抗感染免疫,而较大剂量IL-12则抑制脾淋巴细胞增殖活性,甚至可致免疫病理损害.
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