摘要:目的观察胶胞源性神经营养因子(GDNF)对局灶性脑缺血再灌注大鼠SVZ和SGZ细胞增殖的影响.方法大脑中动脉线栓法制作大鼠局灶性脑缺血再灌注模型,立体定位下侧脑室注射GDNF,应用5-溴脱氧尿核苷(BrdU)标记分裂细胞,观察模型组、GDNF组大鼠SVZ和SGZ神经干细胞的增殖,同时应用Y迷宫监测大鼠学习记忆能力.结果局灶性脑缺血再灌注损伤大鼠GDNF组神经干细胞增殖明显增加,BrdU免疫阳性细胞数与相应对照组比较,差异有显著性意义(P<0.05).GDNF组大鼠学习和记忆能力与相应对照组比较,差异有显著性(P<0.05).结论GDNF可增强局灶性脑缺血SVZ和SGZ细胞增殖能力,外源性GDNF可加速中枢神经损伤的修复.
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