摘要:目的:研究MCP-1-2518G/A基因多态性对冠心病发病的影响。方法:选取冠心病患者300例,正常对照组60例。冠心病患者分急性冠状脉综合征(ACS)组180例以及稳定型心绞痛(SAP)组120例。所有患者行冠状动脉造影(CAG)检查,采用Genisin评分。酶联免疫法测定MCP-1浓度,PCR—RFLP方法检测MCP-1-2518G/A位点多态性,研究MCP-1-2518G/A基因多态性在各组冠心中的变化及作用。结果:MCP-1-2518G/A基因多态性ACS组GG型基因和G等位基因频率分布较SAP组及正常对照组升高,AA型及A等位基因降低,χ2检验P<0.05。②3种基因型间MCP-1浓
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