摘要:胃癌的发生是由正常胃黏膜经历慢性萎缩性胃炎、肠化生、异型增生直至胃癌发生的多阶段渐进性过程。其中肠化生是胃癌尤其是肠型胃癌重要的癌前病变。有研究证实,在肠化生及胃癌的发生过程中,性别决定区Y框蛋白2(SRY related HMG box-2,SOX2)、尾侧型同源转录因子2(caudal related homeobox transcription factor-2,CDX2)和肝细胞核因子(hepatocyte nuclear factor,HNF)4α均有参与,而且3个分子间存在明显相关性。因此,本文对目前SOX2、CDX2和HNF4α与胃癌的相关研究进展作一综述。
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