摘要:目的:研究一线抗结核药物诱导小鼠肝损伤发生过程中NF-κB变化情况。方法:48只昆明小鼠随机分为基线组和HRZ组(INH+RFP+PZA),于灌胃3d、5d、7d、10d、15d后处死。ELISA检测血清中ALT、AST含量。ELISA和RT-PCR检测肝组织中NF-κB、IκB mRNA及蛋白表达水平。结果:肝组织病理学及ALT、AST水平发生改变,提示肝损伤发生。与基线组相比,HRZ组NF-κB mRNA和蛋白水平呈上升趋势,IκB mRNA和蛋白水平逐渐下降。结论:NF-κB通路在抗结核药物性肝损伤小鼠模型中被激活。
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