摘要:肿瘤细胞侵袭力在前列腺癌转移中发挥重要作用,是治疗失败的主要原因。尿激酶纤溶酶原激活剂(uPA)及其受体(uPAR)介导的信号通路参与多种肿瘤的侵袭、存活与转移。本研究旨在探讨uPA与uPAR在前列腺癌细胞侵袭、存活中的生物学作用,以及作为前列腺癌靶向治疗目标的可能性。uPA与uPAR的表达与前列腺癌细胞的转移潜能密切相关,因此通过抑制uPA与uPAR表达的靶向治疗很有前景。检测LNCaP、DU145、PC3三种细胞株侵入细胞外基质的能力,
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