摘要:目的比较耐甲氧西林金黄色葡萄球菌(MRSA)和甲氧西林敏感的金黄色葡萄球菌(MSSA)对氨基糖苷类药物耐药性和耐药基因携带的不同。方法运用K—B法和PCR方法分别对16株MRSA和24株MSSA4种氨基糖苷药物(丁胺卡那霉素、奈替米星、庆大霉素、妥布霉素)耐药性和氨基糖苷类耐药基因进行检测。结果MRSA与MSSA对氨基糖苷类药物耐药率分别为93.8%,62.5%,100%,100%和0.0%,0.0%,29.2%,33.3%,三种氨基糖苷类药物耐药基因aac(6^+)/aph(2″)、aph(3′)Ⅲ、ant(4′,4″)携带率分别为68.8%,62.5%,6.3%和29.2%,8.3%,0.0%。结论MRSA较MSSA对氨基糖苷类药物有着更高的耐药性和耐药基因携带率。MRSA较MSSA对氨基糖苷类药物存在着更为复杂的耐药机制。
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