摘要:目的:探讨cN0期甲状腺乳头状微小癌(papillary thyroid microcarcinoma,PTMC)中央区淋巴结转移的相关因素。方法:回顾分析291例cN0 PTMC患者的资料,探讨与PTMC VI区淋巴结转移相关的临床病理因素。结果:291例患者中央区淋巴结转移占45.7%。单因素分析发现男性肿瘤直径(〉5mm)、肿瘤多灶性、包膜侵犯、BRAF^V600E基因突变和中央区淋巴结转移相关(P〈0.05);多因素分析显示男性、肿瘤直径(〉5mm)、包膜侵犯、BRAF^V600E基因突变是影响PTMC中央区淋巴结转移的独立因素(P〈0.05)。结论:男性、肿瘤直径〉5mm、包膜侵犯、BRAF^V600E突变阳性为PTMC中央区淋巴结转移的高危因素.对高危患者应积极行中央区淋巴结清扫。
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