首页 期刊 色谱 粒度均匀的分子印迹聚合物在手性拆分和生物分析中的应用 【正文】

粒度均匀的分子印迹聚合物在手性拆分和生物分析中的应用

作者:HAGINAKAJun; SANBEHaruyo FacultyofPharmaceuticalSciences; MukogawaWomen'sUniversity; Nishinomiya663-8179; Japan; FacultyofPharmaceuticalSciences; MukogawaWomen'sUniversity; Nishinomiya663-8179; Japan
手性分离   生物分析   分子印迹聚合物   高效液相色谱分析  

摘要:Molecular recognition plays an important role in biological and chemical processes. Since molecular imprinting techniques can afford complementary binding sites for a target molecule, the molecularly imprinted polymer (MIP) for the target molecule has been used for its specific recognition as chromatographic media, solid-phase extraction media, artificial antibodies, membranes and sensors[1-4]. Usually, MIPs were prepared by a bulk polymerization method. However, the disadvantage of the method is that the obtained block polymers should be crushed, ground and sieved to produce high performance liquid chromatographic (HPLC) packing materials. Recently, we prepared the uniformly sized MIPs by a multi-step swelling and polymerization method[5], which is suitable for preparing HPLC packing materials, and renders in situ modification susceptible.

注:因版权方要求,不能公开全文,如需全文,请咨询杂志社

学术咨询 免费咨询 杂志订阅