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神经药理学报杂志 2019年第04期

Acta Neuropharmacologica

主管单位:河北省教育厅
主办单位:河北北方学院;中国药理学会
国际刊号:1673-1484
国内刊号:13-1361/R
审稿时间:1个月内
全年订价:¥ 220.00
创刊:1984年
类别:医药卫生科技
周期:双月刊
发行:河北
语言:中文
起订时间:
曾用名:张家口医学院学报;河北北方学院学报
出版社:行政事业单位类
邮编:075000
主编:张丹参
邮发:18-345
库存:200
主要栏目:
  • 论著
  • 经验交流
  • 综述与讲座
  • 个案报告
  • 医学教育。
  • 诱发支气管哮喘动物模型方法及评价

    作者:张丹参; 张楠 期刊:《神经药理学报》 2019年第04期

    支气管哮喘是呼吸系统疾病中的一种慢性气管变态反应炎症性疾病,由于哮喘病因非常复杂,其发病机制至今尚不十分清楚,许多研究需要通过动物模型进行。该文对诱发哮喘动物模型中动物的性别,体质量,用药量,方法等进行详述,为哮喘机制研究以及哮喘预防和治疗提供基础资料,为进一步开展哮喘相关研究提供帮助。

  • 治疗失眠症中药用药规律分析

    作者:樊帅珂; 方晓艳; 苗明三 期刊:《神经药理学报》 2019年第04期

    目的:分析治疗失眠症及安神中成药的用药规律,为指导临床用药以及新处方的研发提供参考。方法:以《中国药典》2015年版收录治疗失眠及安神中成药为资料来源,使用Excel 2013、SPSS Modeler 14.1统计软件为工具,对纳入标准的中药进行统计处理和关联规则分析。结果:在纳入标准的方剂中,累计出现频数最高的前五味中药分别是甘草(26次,28.57%)、黄芪(24次,26.37%)、五味子(23次,25.27%)、(酸枣仁21次,23.08%)和地黄(21次,23.08%)。药味中,甘(20次,45.45%)、苦(11次,25%)、酸(5次,11.36%)最常见,辛(4次,9.10%),咸(2次,4.54%),涩(1次,2.27%),淡(1次,2.27%)等次之。药性主要集中在寒(8次,30.77%)温(9次,34.62%)平(8次,30.77%)。归经中心经(13次,19.12%)肝经(13次,19.12%)肾经(13次,19.12%)肺经(11次,16.18%)脾经(9次,13.24%)最为常见。结论:由剂型分布可以看出,治疗失眠及安神的中成药剂型种类多样。

  • OA-4 Thioredoxin-1 and Geranylgeranylacetone Resist Neurotoxicity of Amyloid-β

    作者:BAI; Li-ping; LI; Ye; ZHOU; Xiao-shuang; ZHANG; Xian-wen; SUN; Bo; YAN; Chen; DENG; Ru-hua; BAI; Jie 期刊:《神经药理学报》 2019年第04期

    Objective:Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by amyloid-β( Aβ) aggradation in the brain and impairment of cognitive function. Thioredoxin-1( Trx-1) is a redox regulating protein,and plays roles in resisting the oxidative stress and protecting neurons. Our previous study found that Trx-1 improved the cognitive function of Parkinson's Disease (PD) mice. Geranylgeranylacetone (GGA) is an antiulcer drug and induces the expression of Trx-1 in vivo and in vitro. However,whether Trx-1 improves cognitive functions in mice of APP/PS1 or GGA protects SH-SY5Y cells from cytotoxicity induced by Aβ is still unknown. The objective of present is to investigate the roles of Trx-1 and GGA in inhibiting neurotoxicity of Aβ. Methods:We used MTT assay to test the cell viability induced by Aβ(25-35) and western blot to detect the expression of Trx-1 in SH-SY5Y cells. Trx-1 overexpression transgenic mice were hybridized with APP/PS1 transgenic mice to get control,Trx-1,Tx-1/APP/PS1 and APP/PS1 mice. Then we used Morris water maze,high plus maze and object recognition test to detect the cognitive function of different kinds of mice. We also used RT-PCR and western blot to test the mRNA level and expression of Trx-1,APP,PS1 and Aβ. Results:In our present study,we demonstrated that Aβ(25-35) decreased the cell viability and the expression of Trx-1 in SH-SY5Y cells. The cell viability and the expression of Trx-1 were reversed by GGA. Our results showed that the escape latency in APP/PS1 mice was longer when compared with the Trx-1/APP/PS1 mice in Morris water maze and high plus maze. Whereas navigational experiments in Morris water maze result showed that the total number of crossings and the percentage of time spent in the target quadrant were significantly decreased in APP/PS1 mice when compared to Trx-1/APP/PS1 mice. Object recognition 1/APP/PS1 mice. The mRNA levels and the expression of APP,PS1 and Aβ were decreased in Trx- 1/APP/PS1 mice when compared to APP/PS1 mice

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