摘要:目的研究HBV逆转录酶YMDD变异对肝功能和病毒指标的影响及其临床意义。方法选择临床治疗的YMDD变异组33例和YMDD野生组28例患者,统计分析两组间病毒DNA载量、ALT、TBil、DeRitis比值和HBeAg转阴率的差异。结果 YMDD变异组和YMDD野生组间病毒DNA载量、ALT、TBil、DeRitis比值和HBeAg转阴率差异无统计学意义。结论 YMDD突变型和野生型HBV对患者肝细胞损伤、肝脏生物转化、乙肝慢性化和HBeAg转阴率等方面无显著差异。
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