摘要:目的:探讨云南汉族FcγRⅡA基因多态性与SLE易感性的关系.方法:提取86例SLE患者和40例健康对照者的静脉血DNA,分别用PCR+BSTUI酶切检测FvcγRⅡA基因型,比较各基因型检出率的差别;并比较不同基因型患者在疾病活动期的临床表型.结果:患者组FcγRⅡA-R/R的检出率高于健康对照组;R/R组皮疹阳性率及血清IgG增高的阳性率明显高于H/H组.结论:FcγRⅡA-R/R基因型可能是SLE的遗传易感因素.
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