摘要：目的:探讨肿瘤坏死因子-α在癫痫中的作用机制.方法:应用免疫组织化学的方法研究TNF-α对戊四氮致癫痫大鼠海马Glu能神经元和GABA能神经元的影响.结果:大鼠海马谷氨酸能神经元的改变; 戊四氮致癫痫组明显高于正常对照组,TNF-α干扰组明显高于戊四氮致癫痫组和正常对照组.大鼠海马GABA能神经元的改变; 戊四氮致癫痫组明显低于正常对照组, TNF-α干扰组明显低于戊四氮致癫痫组和正常对照组.结论:TNF-α可以通过增强海马谷氨酸能神经元的活性和降低GABA能神经元的活性而促进癫痫的发生和发展.
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