南京医科大学学报·自然科学版杂志 北大期刊 统计源期刊

Use of biologically synthesized antimicrobial nanoparticles for improving peritoneal dialysis technique:a translational research perspective

作者：Dinesh; Kumar 刊期：2016年第05期

Deciphering the role of hedgehog signaling in pancreatic cancer

作者：Dongsheng; Gu; Kelly; E; Schlotman; Jingwu; Xie 刊期：2016年第05期

Pancreatic cancer,mostly pancreatic ductal adenocarcinoma(PDAC),is a leading cause of cancer-related death in the US,with a dismal median survival of 6 months.Thus,there is an urgent unmet need to identify ways to diagnose and to treat this deadly cancer.Although a number of genetic changes have been identified in pa...

Autoantibodies in Alzheimer’s disease:potential biomarkers,pathogenic roles,and therapeutic implications

作者：Jianming; Wu; Ling; Li 刊期：2016年第05期

Alzheimer’s disease(AD) is a prevalent and debilitating neurodegenerative disorder in the elderly.The etiology of AD has not been fully defined and currently there is no cure for this devastating disease.Compelling evidence suggests that the immune system plays a critical role in the pathophysiology of AD.Autoantibo...

Effects of renal sympathetic denervation on cardiac systolic function after myocardial infarction in rats

作者：Jiqun; Guo; Zhongxia; Zhou; Zhenzhen; Li; Qian; Liu; Guoqing; Zhu; Qijun; Shan 刊期：2016年第05期

This study investigated the therapeutic effects of renal denervation on cardiac systolic function after myocardial infarction(MI) in rats and the mechanism involved.Fifty male SD rats were randomly assigned to the sham group(n = 15),the MI group(n = 20),and the MI plus renal denervation group(n = 15).MI was establish...

Effects of epinephrine on angiogenesis-related gene expressions in cultured rat cardiomyocytes

作者：Henry; Liu; Lisa; Sangkum; Geoffrey; Liu; Michael; Green; Marilyn; Li; Alan; Kaye 刊期：2016年第05期

Epinephrine is often used for the treatment of patients with heart failure,low cardiac output and cardiac arrest.It can acutely improve hemodynamic parameters;however,it does not seem to improve longer term clinical outcomes.Therefore,we hypothesized that epinephrine may induce unfavorable changes in gene expression ...

Developing a tool for nurses to assess risk of infection in pediatric oncology patients in China:a modified Delphi study

作者：Yufeng; Zhou; Yan; Cui; Hong; Wang; Fang; Wang; Chao; Lu; Yan; Shen 刊期：2016年第05期

New insights into estrogenic regulation of O~6-methylguanine DNA-methyltransferase(MGMT) in human breast cancer cells:Co-degradation of ER-α and MGMT proteins by fulvestrant or O~6-benzylguanine indicates fresh avenues for therapy

作者：Ameya; Paranjpe; Nathan; I.Bailey; Santhi; Konduri; George; C.Bobustuc; Francis; Ali-Osman; Mohd.A.Yusuf; Surendra; R.Punganuru; Hanumantha; Rao; Madala; Debasish; Basak; AGM; Mostofa; Kalkunte; S.Srivenugopal 刊期：2016年第05期

Endocrine therapy using estrogen receptor-α(ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers.To exploit any DNA repair deficiencies associated with endocrine therapy,we investigated the functional and physical interactions of ER-α with O~6-methylgua...

Partial aortic root remodeling for root reconstruction in patients with acute type A dissection

作者：Fuhua; Huang; Liangpeng; Li; Wei; Qin; Cunhua; Su; Liming; Wang; Liqiong; Xiao; Xin; Chen 刊期：2016年第05期

In the present study,we reported our experience with partial aortic root remodeling for root reconstruction in patients with acute type A dissection,which involves in non-coronary sinus and/or the right coronary sinus with just one trimmed Dacron graft.Between February 2001 and May 2010,we performed partial aortic ro...

The impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity during treatment of osteoporotic vertebral compression fractures with balloon kyphoplasty

作者：Qingqing; Li; Long; Xiao; Jianwei; Zhang; Jin; Fan; Wei; Zhou; Guoyong; Yin; Yongxin; Ren 刊期：2016年第05期

This retrospective study investigated the impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity in 144 patients with osteoporotic vertebral compression fracture(OVCF),who received balloon kyphoplasty.Patients were divided into four groups:Group 1 had no superior endplate fracture,G...

Effects of aspartame on hsp70,bcl-2 and bax expression in immune organs of Wistar albino rats

作者：Arbind; Kumar; Choudhary; Rathinasamy; Sheela; Devi 刊期：2016年第05期

Aspartame,a 'first generation sweetener',is widely used in a variety of foods,beverages,and medicine.The FDA has determined the acceptable daily intake(ADI) value of aspartame to be 50 mg/kg-day,while the JECFA(Joint FAO/WHO Expert Committee on Food Additives) has set this value at 40 mg/kg of body weight/day.Safety ...

Laparoscopic abdomino-perineal resection for patients with anorectal malignant melanoma:a report of 4 cases

作者：Jun; Han; Chuanbing; Shi; Xiaogang; Dong; Jie; Wang; Hao; Wen; Baolin; Wang; Zhenyu; He 刊期：2016年第05期

Anorectal malignant melanoma is a very rare but lethal disease.Patients with anorectal malignant melanoma commonly complain for changes in bowel habits and rectal bleeding.Therefore,anorectal malignant melanoma is often misdiagnosed as hemorrhoids,polyp or rectal cancer.Surgery is the mainstay of treatment for patien...