摘要:乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)是乙型病毒性肝炎的特征性标志物。酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)二步法极大地提高了HBsAg的检出率,但对于低水平表达尤其是突变型HBsAg的检测能力仍然有限。有研究显示,单独乙型肝炎核心抗体(hepatitis B core antibody,HBcAb)阳性患者的乙型肝炎病毒(hepatitis B virus,HBV)DNA检出率达8.1%[1],提示临床工作中对HBcAb阳性者的进一步检测不容忽视。本研究分别采用ELISA和化学发光微粒子免疫法(chemiluminescent microparticle immunoassay,CMIA)检测HBcAb阳性的不同模式患者血清中的HBsAg,比较2种方法对HBsAg的检出情况。
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