摘要：以2,4-二氯-5-氟苯乙酮为原料,通过β-酮酸酯化,与原甲酸三乙酯缩合,同2-氨基嘧啶发生取代反应,再经环合、硼络合和哌嗪化反应合成得到了N-嘧啶取代喹诺酮抗菌化合物,总收率为22.4%,并研究了其抗菌活性.
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