摘要:Notch信号通路是一个在生物进化上十分保守的信号转导系统,其广泛存在于脊椎动物和无脊椎动物体内,Notch信号通路通过受体与配体之间的相互作用在细胞增殖、分化、发育、凋亡中起关键作用。Notch信号通路对卵泡发育早期也有重要调节作用,Notch信号通路发生异常会引发原始卵泡发育受到抑制、颗粒细胞脱落,甚至出现多卵母细胞卵泡等异常发育情况。
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