摘要:[目的]探讨CYP1A1基因异亮氨酸(Ile)-缬氨酸(Val)位点多态性和GSTM1缺失与肺癌易感性的关系.[方法]以病例-对照方法,采用PCR技术检测82例原发性肺癌患者和91例对照者的CYP1A1基因Ile-Val位点多态性与GSTM1基因的缺失.[结果]Ile-Val 3种多态基因型在肺癌组和对照组分布差异有显著性(P《0.05),Ile/Val、Val/Val基因型在肺癌组的分布频率明显高于对照组;logistic回归分析结果显示Ile/Val、Val/Val基因型患肺癌的危险性分别是Ile/Ile基因型的1.969(95%CI:1.012~3.828)倍和3.150倍(95%CI:1.278~7.761);GSTM1基因缺失在两组的分布频率差异有显著性(P《0.05,OR=2.157).进一步联合CYP1A1多态性分析显示GSTM1缺失的个体同时携带Ile/Val或Val/Val基因型患肺癌的危险性较单独具有一种危险因子患肺癌的危险性显著增加(OR=5.538).[结论]CYP1A1第7外显子的Ile/Val、Val/Val基因型和GSTM1缺失与肺癌的易感性有关,可望作为肺癌易感人群筛选的重要指标.
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