摘要：细胞周期关卡激酶ATM(Ataxia Telangiectasia mutated)属于PI-3K家族,调控DNA损伤修复和凋亡通路.ATM能识别DNA损伤并被激活,通过磷酸化其下游相应蛋白,调节细胞周期各关卡,使损伤DNA得以修复.如修复失败,则启动凋亡通路,以避免受损DNA随细胞分裂进入子代细胞.
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