摘要:成纤维细胞生长因子(FGF)-23是FGF家族中的新成员.FGF-23基因位于人染色体12p13,编码含有251个氨基酸的多肽.FGF-23通过抑制肾OK细胞的磷酸盐转运,特异性减少肾磷的重吸收,从而降低血磷水平.FGF-23基因自身突变、PHEX基因突变和肿瘤源性FGF-23分泌增多引起FGF-23降解减少和生物活性增高,导致血循环中FGF-23水平升高,从而引起肾磷重吸收障碍,导致低血磷性疾病.
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