摘要：RNA干扰(RNAi)是通过双链RNA被核酸酶切割形成21-25 nt的干扰性小RNA,即siRNA,由siRNA介导识别并靶向切割同源性靶mRNA分子而实现的基因沉默.最近有若干将RNAi技术应用于丙型肝炎基因治疗的研究,证实其不仅对丙型肝炎病毒RNA的复制和蛋白表达具有明显抑制作用,还能通过抑制Fas基因的表达,减轻肝细胞凋亡引起的损伤.
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