摘要:多形性胶质母细胞瘤(glioblastoma,GBM)是成人中最常见恶性程度最高的原发性脑胶质瘤。受体酪氨酸激酶(receptor tyrosine kinase,RTK)及其下游信号通路异常激活能够促进GBM的恶性进展。肿瘤微环境(tumor microenvironment,TME)是GBM侵袭过程的关键调控因素,TME中的细胞外基质(extracellular matrix,ECM)与整合素(integrin)结合导致促进GBM侵袭的相关信号通路激活,ECM/integrin相关通路与RTK下游信号通路整合进一步促进GBM恶性进展。因此,对RTK及其下游信号通路与ECM/integrin通路交叉整合对GBM侵袭作用的阐述有助于为GBM治疗靶点提供新的视角。
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