摘要:Toll样受体(Toll-like receptors,TLRs)家族通过识别病原体相关分子模式(pathogen associated molecular pattern,PAMP)激活免疫细胞,在天然免疫防御病原体中起着重要作用.目前在哺乳类中至少存在10个TLRs(TLR1-10)成员,其中TLR9是识别细菌CpG-DNA的必需的模式识别受体(patttern recognition receptor,PRR).本文综述了TLR9的结构、功能及信号传导机制.
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