摘要：目的研究TNF-α和(或)IFN-γ对皮肤角细胞、成纤维细胞产生TARC和MDC的影响.方法采用ELISA、RT-PCR等方法检测人角细胞株赳aCaT细胞和人成纤维细胞株-NG1RGB细胞TARC、MDC的表达.结果TNF-α和(或)IFN-γ作用下的皮肤角细胞产生TARC,而成纤维细胞不能表达;MDC的表达情况与TARC的结果相同.结论在TNF-α和(或)IFN-γ作用的角细胞、成纤维细胞上,TARC和MDC两种趋化因子具有相同的产生机制.
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